Status:
UNKNOWN
Timing of Thyroxine Dose In Ramadan
Lead Sponsor:
King Abdullah International Medical Research Center
Conditions:
Hypothyroidism
Eligibility:
All Genders
18-80 years
Phase:
NA
Brief Summary
A Randomized trial comparing two different timing of taking thyroxine in patients with Hypothyroidism during fasting the month of Ramadan.
Detailed Description
To date there is debate regarding the best timing of L-thyroxine administration during Ramadan as sufficient evidence is lacking. This study aims to compare two-time points of levothyroxine intake dur...
Eligibility Criteria
Inclusion
- Saudi patient (males and female) above 18 years with Primary hypothyroidism on levothyroxine replacement who are willing to fast during Ramadan.
- Patients with controlled thyroid function for last 3 months on same dose of levothyroxine.
Exclusion
- Pregnant or lactating women.
- Uncontrolled thyroid function test three months prior Ramadan.
- Thyroid cancer patients who require suppressed TSH.
- Central Hypothyroidism, patient with acute illness.
- Patients diagnosed with malabsorption i.e., Celiac Disease, Short bowel, Bariatric surgeries
- Use of certain Medications like systemic glucocorticoids, activated charcoal, sucralfate, aluminum hydroxide antacid, bile acid sequestrants, iron, calcium carbonate, PPI, rifampicin, and antiepileptic medications
- Renal or hepatic disease:
- Creatinine clearance \<0.6 ml/s or serum creatinine ≥200 μmol/l
- Alanine transferase ≥2.5 times the upper limit of normal
- Active liver disease including jaundice, chronic hepatitis, previous liver transplant
- Unwillingness to be randomized or to sign informed consent
- Known Psychiatric Disorders
- Known uncontrolled substance abuse or alcoholism
Key Trial Info
Start Date :
March 14 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 30 2022
Estimated Enrollment :
250 Patients enrolled
Trial Details
Trial ID
NCT05421468
Start Date
March 14 2022
End Date
October 30 2022
Last Update
June 16 2022
Active Locations (2)
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1
Reem Alamoudi
Jeddah, Saudi Arabia, 21423
2
KingAbullahIMRC
Jeddah, Saudi Arabia