Status:
UNKNOWN
A 'Non-Invasive' Breath Test to Determine Anabolic Sensitivity in Females
Lead Sponsor:
University of Toronto
Conditions:
Dietary Protein
Female Protein Metabolism
Eligibility:
FEMALE
18-35 years
Phase:
NA
Brief Summary
The maintenance of lean body mass, especially skeletal muscle, is vital for optimal health and performance across the lifespan. The protein component of lean body mass is in a constant state of turnov...
Detailed Description
The objective of the present study is to validate the use of an oral L-\[13C\]-leucine stable isotope tracer, preferentially metabolized within skeletal muscle, to detect an exercise-induced increase ...
Eligibility Criteria
Inclusion
- Female sex
- 18-35 years of age
- BMI ≥18.5 kg/m2 and ≤ 30 kg/m2
- Eumenorrheic (self-reported menstruation for prior 3 consecutive months)
- Recreationally active; currently performing structured exercise (e.g. running, weightlifting, team-sport activity) at least once per week for ≥ 6 months before enrolment
Exclusion
- Use of oral contraceptives
- Inability to perform physical activity as determined by the PAR-Q+
- Inability to adhere to protocol guidelines (e.g. alcohol, caffeine, habitual diet)
- Regular tobacco use
- Illicit drug use (e.g. growth hormone, testosterone, etc...)
- Diagnosed medical condition under the care of a physician (e.g. type 2 diabetes)
- Inability to abstain from supplements (e.g. protein, creatine, HMB, BCAA, phosphatidic acid, etc...) at least three weeks before the trial
- Individuals on any medications known to affect protein metabolism (e.g. corticosteroids, non-steroidal anti-inflammatories, and/or prescription-strength acne medications)
Key Trial Info
Start Date :
June 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2023
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05422300
Start Date
June 20 2022
End Date
December 31 2023
Last Update
July 13 2023
Active Locations (1)
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1
University of Toronto
Toronto, Ontario, Canada, M5S 2C9