Status:
UNKNOWN
Evaluation of the EEG Connectivity Using Predominant Dexmedetomidine as Anesthetic in Fragile Brains
Lead Sponsor:
Universidad del Desarrollo
Collaborating Sponsors:
Klinikum rechts der Isar Technische Universität München
Conditions:
Aging Problems
Eligibility:
All Genders
70+ years
Brief Summary
Elderly brains that present a lower intrinsic cortical activity are very dependent on arousal feeding. In these patients, a strong blockade of afferences generates a synchronic state with a high tende...
Detailed Description
Research question: Does subcortical drug-based anesthesia allow better recovery of consciousness (integration of information) than the classic gabaergic drug-based technique in elderly and fragile bra...
Eligibility Criteria
Inclusion
- Eligibility criteria Inclusion criteria
- surgery over 60 min
- ASA I - II
- Age: over 70 years old
Exclusion
- \- Neurological, or systemic disease that affects the central nervous system in a secondary way
- Abnormal admission neurological physical exam
- Consumption of benzodiazepines, tricyclic antidepressants, sympathomimetics, modafinil, opioid analgesics, histaminergic, antihistamines, cholinergic, anticholinergics, dopaminergic, antidopaminergic, and antihypertensive with alpha-agonist effect in the last 48 hours.
- History of adverse or allergic reactions to Propofol (allergy to soy or any other component of it)
- History of alcohol or drug abuse
- Subjects with "fast sequence induction" indication
- Withdrawal criteria:
- Patients presenting with any adverse event during induction (excitation, hypotension, bradycardia \<40 x min, nausea).
- Subsequent refusal to participate in the study
Key Trial Info
Start Date :
January 2 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
June 30 2022
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05425069
Start Date
January 2 2022
End Date
June 30 2022
Last Update
June 21 2022
Active Locations (1)
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1
Hospital Base San Jose
Osorno, Los Lagos Region, Chile