Status:
RECRUITING
Translational PKPD Modeling of Anti-infective Drugs Used in Pediatric Units.
Lead Sponsor:
Poznan University of Medical Sciences
Collaborating Sponsors:
University at Buffalo
The Greater Poland Cancer Centre
Conditions:
Population Modeling of Anti-infective Drugs
Eligibility:
All Genders
Brief Summary
Pharmacokinetic and pharmacodynamic modeling (PKPD) is becoming an essential tool for optimizing pharmacotherapy. Building mechanistic models allows determining the relationship between the dose, conc...
Detailed Description
Cefotaxime and meropenem are broad-spectrum antibiotics, most commonly prescribed in pediatric and adult intensive care units. Unfortunately, the applied dosing regimens based on the results obtained ...
Eligibility Criteria
Inclusion
- Obtaining informed consent from the patient/parent of the patient
- A bacterial and fungal infection that requires the use of at least one of the drugs listed based on clinical indications and the attending physician's decision.
Exclusion
- Proven allergic reaction to medications used
- No written consent
- Contraindications in SmPC
- Combination therapy with at least two antibacterial drugs and/or at least two antifungal drugs
Key Trial Info
Start Date :
October 1 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 30 2025
Estimated Enrollment :
150 Patients enrolled
Trial Details
Trial ID
NCT05426499
Start Date
October 1 2021
End Date
September 30 2025
Last Update
May 31 2025
Active Locations (4)
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1
Szpital Kliniczny im. Karola Jonschera Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu
Poznan, Greater Poland Voivodeship, Poland, 60-572
2
Poznan University of Medical Sciences, Department of Clinical Pharmacy and Biopharmacy
Poznan, Greater Poland Voivodeship, Poland, 60-806
3
Szpital Kliniczny im. Heliodora Święcickiego UMP
Poznan, Greater Poland Voivodeship, Poland, 61-848
4
Wielkopolskie Centrum Onkologii
Poznan, Greater Poland Voivodeship, Poland, 61-866