Status:
UNKNOWN
Imaging Biomarkers of Neuroplasticity and Neurodegeneration in the Living Human Brain
Lead Sponsor:
Thiel, Alexander, M.D.
Collaborating Sponsors:
Canadian Institutes of Health Research (CIHR)
University of Alberta
Conditions:
Normal Healthy Adults
Eligibility:
All Genders
18-89 years
Phase:
PHASE1
Brief Summary
Following our recently completed whole body dosimetry study for \[18F\] TRACK in 6 healthy control subjects, the objective of this project is to evaluate brain uptake, regional distribution and in viv...
Detailed Description
We propose to use the radiotracer \[18F\] TRACK to non-invasively image the concentration of TrkB/C in the living human brain with Positron Emission Tomography in 3 different age cohorts. The differen...
Eligibility Criteria
Inclusion
- In order to be considered a healthy control, participants will have a Clinical Dementia Rating (CDR) of 0, Montreal Cognitive Assessment (MoCA) greater than or equal to 26 and Mini-Mental State Exam (MMSE) of 24 or greater, with normal results on the Logical Memory 2 score from the Wechsler Memory Scale-Revise (cut-offs adjusted by education level), and normal scores on the Jessen questions for subjective memory complaints \[21\]. For the arterial catheter insertion, participants must have two viable arteries of the hand/arm. Women of childbearing potential must undergo a urine pregnancy test and may only be included if the urine pregnancy test is negative.
Exclusion
Key Trial Info
Start Date :
August 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 1 2024
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05427656
Start Date
August 1 2022
End Date
August 1 2024
Last Update
July 21 2022
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