Status:
UNKNOWN
Thymol on Netrin-1 on Obese Patients
Lead Sponsor:
Centro Universitario de Ciencias de la Salud, Mexico
Conditions:
Inflammatory Response
Obesity
Eligibility:
All Genders
18-35 years
Phase:
PHASE2
Brief Summary
The prevalence of obesity in Mexico is 35.4%, and it is considered a risk factor for the development of diabetes, systemic arterial hypertension and dyslipidemia. Obesity due to the increased distribu...
Detailed Description
Objective: To evaluate the effect of thymol administration on the serum concentration of netrin-1 in obese subjects. Material and methods: this is a randomized, double-blind, placebo-controlled clini...
Eligibility Criteria
Inclusion
- Subjects between 18 and 35 years old.
- BMI ≥ 30.0 and ≤35.0
- Systolic blood pressure less than 135 mmHg.
- Diastolic blood pressure less than 85 mmHg.
Exclusion
- Subjects who are known to have a diagnosis, receive treatment, or are observed with:
- Rheumatological and / or thyroid disease.
- Chronic kidney disease and / or CKD-EPI glomerular filtration rate less than 60 ml / min / 1.72m2.
- Innate alterations of metabolism.
- Elevation of transaminases 2 times higher than normal.
- Total cholesterol greater than 250 mg / dl.
- Triglycerides greater than 300 mg / dl.
- Subjects presenting with acute illness, hospitalization, or drug treatment presented in the last 12 weeks prior to the study selection visit.
- Subjects with symptoms consistent with the definition of a probable case of COVID-19, as well as any subject with a diagnosis of COVID-19.
- Subjects who have had blood transfusions in the last 3 months.
- Regular smokers.
- Pregnant or lactating women.
- Women with a desire for pregnancy or who do not have a double barrier or progestin-only contraceptive method.
Key Trial Info
Start Date :
April 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 30 2022
Estimated Enrollment :
30 Patients enrolled
Trial Details
Trial ID
NCT05427721
Start Date
April 1 2022
End Date
December 30 2022
Last Update
June 22 2022
Active Locations (1)
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1
INTEC, CUCS, Universidad de Guadalajara
Guadalajara, Jalisco, Mexico, 4430