Status:
UNKNOWN
Cardiac Responsiveness Assessment by CO2
Lead Sponsor:
Hospices Civils de Lyon
Conditions:
VCO2 Variation in Intensive Care as a Marker of Fluid Responsiveness
Cardiac Index Variation Transpulmonary Thermodilution in Patients on Controlled Ventilation With Shock
Eligibility:
All Genders
10+ years
Brief Summary
The increase of cardiac output resulting from increased blood volume (systolic ejection volume) during intravenous fluid administration defines a state of fluid responsiveness. Fluid responsiveness i...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patient hospitalized in intensive care.
- Patient sedated and mechanically ventilated in Volume Assisted Controlled mode.
- Patient with hypotension (MAP \<65 mmHg OR SAP \<90 mmHg) AND / OR under continuous infusion of Norepinephrine / Dobutamine / Epinephrine
- Patient equipped with a cardiac output measurement system by transpulmonary thermodilution (PICCO®) with a femoral arterial module; as well as a central venous route in the superior or inferior vena cava territory.
- Exclusion Criteria :
- Patient under 18 years old
- Patient under guardianship without the possible consent of the guardian
- Pregnant woman
- Pathologies and maneuvers strongly affecting CO2 purification: Diagnosed pulmonary embolism, Prone positioning for less than 60 minutes, Exogenous intake of sodium bicarbonate less than 60 minutes ago (with the exception of an renal replacement therapy in place for more than 60 minutes)
- Recent change in respiratory quotient: Change in enteral or parenteral nutrition solution for less than 3 hours
- Pathology affecting CO2 metabolism: Fever\> 39 ° c, Intense chills.
- Patients with unstable ventilation over the hour before inclusion.
Exclusion
Key Trial Info
Start Date :
September 1 2022
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 1 2023
Estimated Enrollment :
100 Patients enrolled
Trial Details
Trial ID
NCT05430880
Start Date
September 1 2022
End Date
September 1 2023
Last Update
June 24 2022
Active Locations (1)
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1
Hôpital Edouard Herriot, Anesthésie-réanimation
Lyon, France, 69003