Status:
COMPLETED
Evaluating the Effects of Omeprazole on the Pharmacokinetics of XS004 (Dasatinib) Tablets in Healthy Adult Subjects Under Fasting Conditions
Lead Sponsor:
Xspray Pharma AB
Collaborating Sponsors:
Axis Clinicals Limited
Conditions:
Pharmacokinetics
Drug Interactions
Eligibility:
All Genders
18-60 years
Phase:
PHASE1
Brief Summary
In this open label, single-sequence study, subjects received one dose of XS004 Dasatinib Amorphous Solid Dispersion Film-Coated Tablet, 90 mg Test Formulation at the start of study on Day 1 and Day 6....
Eligibility Criteria
Inclusion
- Age: 18-60 years
- Sex: Healthy adult males (sterile or using contraception) and females of non-childbearing potential
- Clinical laboratory values should be within the laboratory's stated normal range. If not within this range, they must be without clinical significance, as determined by the Investigator
- No clinically significant diseases captured in the medical history or evidence of clinically significant findings on the physical examination (including vital signs) and/or ECG, as determined by the Investigator
- Any abnormalities/deviations from the acceptable range of medical history, laboratory values, ECG, and vital signs that might be considered clinically relevant by the study physician or Investigator will be evaluated as individual cases
- Able to comply with study procedures, in the opinion of the Investigator(s)
- Willing to give written consent, pregnancy outcome consent, and adhere to all the requirements of this protocol
Exclusion
- Any major illness in the last three months or any significant ongoing chronic medical illness
- Does not agree to consume the provided meals
- Participation in any clinical trial 30 days prior to dosing
- Positive results for drugs of abuse or alcohol breath analysis prior to dosing
- Positive screening results to HIV Ag/Ab Combo, Hepatitis B surface Antigen, Hepatitis C Virus, or anti-HBc tests
- Females currently breastfeeding, demonstrating a positive pregnancy screen, or using hormone replacement therapy within three months prior to dosing
Key Trial Info
Start Date :
November 1 2020
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 19 2020
Estimated Enrollment :
17 Patients enrolled
Trial Details
Trial ID
NCT05433896
Start Date
November 1 2020
End Date
December 19 2020
Last Update
June 27 2022
Active Locations (1)
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1
AXIS Clinicals
Dilworth, Minnesota, United States, 56529-1342