Status:
RECRUITING
Whole Genome Sequencing (ChromoSeq) as an Adjunct to Conventional Genomic Profiling in MDS
Lead Sponsor:
Washington University School of Medicine
Collaborating Sponsors:
American Society of Hematology
Edward P. Evans Foundation
Conditions:
Whole Genome Sequencing
Myelodysplastic Syndromes
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This is a single institution, prospective study of the whole genome sequencing assay, ChromoSeq. Using prospectively collected patient data, coupled with physician surveys, the investigators seek to d...
Eligibility Criteria
Inclusion
- Inclusion Criteria Patient:
- Diagnosis of MDS, or a clinical suspicion for a new diagnosis of MDS, for whom routine diagnostic testing is requested or planned to be requested.
- Seen in the outpatient setting.
- Not been previously treated with disease-modifying therapy (such as lenalidomide or hypomethylating agents).
- Note: Patients who have received transfusional support, erythropoietin-stimulating agents, growth factor support, or luspatercept are eligible.
- At least 18 years of age.
- Able to understand and willing to sign an IRB approved written informed consent document.
- Inclusion Criteria Physician:
- Treating physician at Washington University School of Medicine who directs therapy for individuals with hematologic malignancies.
- Able and willing to complete standardized questionnaires about stakeholder perceptions of ChromoSeq during the ChromoSeq implementation process. (Written documentation of informed consent is not required.)
- Exclusion Criteria Patient:
- Younger than 18 years of age
- Exclusion Criteria Physician
- Does not treat patients at Washington University School of Medicine
Exclusion
Key Trial Info
Start Date :
July 27 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 31 2027
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05434598
Start Date
July 27 2022
End Date
August 31 2027
Last Update
December 11 2025
Active Locations (1)
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1
Washington University School of Medicine
St Louis, Missouri, United States, 63110