Status:
COMPLETED
Effect of Intraoperative Dexmedetomidine on Postoperative Delirium in Elderly Patients Undergoing Major Abdominal Surgery
Lead Sponsor:
Chinese PLA General Hospital
Collaborating Sponsors:
Beijing Tiantan Hospital
Conditions:
Delirium in Old Age
Eligibility:
All Genders
65+ years
Phase:
NA
Brief Summary
To observe the effect of intraoperative dexmedetomidine on the incidence of postoperative delirium, postoperative analgesic drug requirements and pain scores in elderly patients undergoing major abdom...
Detailed Description
This study is a multicenter, randomized, double-blind, placebo-controlled trial. Three hundred patients undergoing elective major abdominal surgery were randomized to the intervention and control grou...
Eligibility Criteria
Inclusion
- Patients over 65 years old
- Patients undergoing elective major abdominal surgery
- Written informed consent was obtained
Exclusion
- Patients with severe preoperative cognitive impairment (MMSE ≤ 20) who are unable to undergo a follow-up evaluation.
- Patients with history of psychiatric or neurological disorders.
- Patients with body mass index ≤ 18 or ≥ 30
- Patients with severe bradycardia (heart rate less than 40 beats per minute)
- Patients with pathological sinus node syndrome or grade 2 or greater AV block
- Patients with severe hepatic or renal insufficiency.
- Patients with severe hypertension (systolic blood pressure ≥ 180 mmHg or diastolic blood pressure ≥ 110 mmHg)
Key Trial Info
Start Date :
July 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
May 1 2025
Estimated Enrollment :
268 Patients enrolled
Trial Details
Trial ID
NCT05436964
Start Date
July 1 2022
End Date
May 1 2025
Last Update
November 19 2025
Active Locations (3)
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1
Beijing Tiantan Hospital,Capital Medical University
Beijing, China
2
Chinese PLA General Hospital
Beijing, China
3
Central theater General Hospital
Wuhan, China