Status:

RECRUITING

Prehospital Analgesia INtervention Trial (PAIN)

Lead Sponsor:

Jason Sperry

Collaborating Sponsors:

United States Department of Defense

Conditions:

Traumatic Injury

Eligibility:

All Genders

18+ years

Phase:

PHASE3

Brief Summary

The Prehospital Analgesia INtervention trial (PAIN) is a proposed 4 year (3-year enrollment) multicenter, prehospital, randomized, double-blind, clinical trial that will enroll approximately 994 patie...

Eligibility Criteria

Inclusion

  • Transport after injury to a participating PAIN Trauma center
  • 2\. Patient with compensated shock as defined by Shock Index (SI) ≥0.9 or Heart Rate (HR) ≥115.
  • Intravenous pain medication indicated (CPOT≥2, NRS≥5) prior to arrival at the trauma center

Exclusion

  • No IV access
  • Age \<18 years
  • Females \<50 years of age
  • SBP\>180 mmHg at time of enrollment
  • Advanced airway management prior to first dose administration
  • Known allergy to fentanyl citrate or ketamine hydrochloride
  • Known prisoner
  • Objection to study voiced by subject or family member at scene
  • Pain treatment contraindicated by local protocol
  • Wearing a "NO PAIN STUDY" bracelet

Key Trial Info

Start Date :

November 27 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

July 1 2029

Estimated Enrollment :

994 Patients enrolled

Trial Details

Trial ID

NCT05437575

Start Date

November 27 2023

End Date

July 1 2029

Last Update

December 17 2025

Active Locations (10)

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Page 1 of 3 (10 locations)

1

University of California, San Diego

San Diego, California, United States, 92103

2

Zuckerberg San Francisco General Hospital

San Francisco, California, United States, 94110

3

Cooper University Health Care

Camden, New Jersey, United States, 08103

4

Atrium Health and Carolinas Medical Center

Charlotte, North Carolina, United States, 28203