Status:
RECRUITING
Decoding and Modulating Affective Brain States
Lead Sponsor:
University of Pennsylvania
Conditions:
Rumination
Major Depressive Disorder
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
The research study is being conducted to study brain patterns of negative emotion and develop personalized brain stimulation protocols to disrupt these patterns with transcranial magnetic stimulation ...
Detailed Description
The study involves 11 visits over approximately 10 weeks, depending on scanner availability and scheduling. See below for the study schedule with a summary of the procedures: * Visit 1: Screening Pro...
Eligibility Criteria
Inclusion
- Inclusion criteria:
- 18-65 years old
- Patient Health Questionnaire (PHQ-9 score) = or \> than 10
- Comprehension of instructions in the English language.
- Capacity to provide informed consent and follow study procedures.
- Availability for the duration of the study.
- Exclusion Criteria:
- Diagnosis of bipolar disorder (as PI discretion), schizophrenia or other psychotic disorder
- Recent use of psychoactive medications or substances as determined by investigators
- History of neurological disorder or traumatic brain injury (other than mild)
- Unable to have an MRI scan, or current or prior medical condition that could interfere with the collection or interpretation of MRI data
- Unable to receive or tolerate TMS
- Implanted devices, such as an aneurysm clip or cardiac pacemaker
- History of stroke, epilepsy, or brain scarring
- Pregnant, nursing, or trying to become pregnant (self-attestation alone)
- During this study, participants are asked to:
- Refrain from substance use (including marijuana and illicit drugs) for duration of the study (self-attestation alone).
- Abstain from alcohol for 24 hours before the MRI scans (self-attestation alone).
- Abstain from increasing caffeine intake or begin taking any new medications (self-attestation alone).
Exclusion
Key Trial Info
Start Date :
February 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05437705
Start Date
February 21 2023
End Date
December 1 2028
Last Update
September 3 2025
Active Locations (1)
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1
University of Pennsylvania
Philadelphia, Pennsylvania, United States, 19104