Status:
COMPLETED
Effects of Blood-flow Restricted Exercise Compared to Standard Rehabilitation in Patients With Knee Osteoarthritis
Lead Sponsor:
Bispebjerg Hospital
Collaborating Sponsors:
University of Southern Denmark
Gigtforeningen
Conditions:
Osteoarthritis, Knee
Eligibility:
All Genders
Phase:
NA
Brief Summary
The purpose of this study is to investigate the effect of low-intensity BFR exercise on joint pain, muscle mass, and mechanical muscle function compared to standard rehabilitering in adults with knee-...
Detailed Description
Osteoarthritis (OA) is a common disease in Denmark with high socioeconomical costs. Representing the most widespread non-medical and non-operative treatment modality both internationally and in Denmar...
Eligibility Criteria
Inclusion
- All participants must meet the American College of Rheumatology (ACR) criteria for OA 35.
- Visible OA on X-ray pictures (Kellgren \& Lawrence grade 2-3).
- Unilateral pain and functional limitation for a minimum of 3 months.
- Be able to voluntarily (i.e. unassisted) perform a 90 degrees flexion in the knee.
- Be able to perform the machine exercise (knee extension) planned for the BFR training.
- Danish-speaking.
- No longer travel planned within the intervention period.
Exclusion
- Kellgren \& Lawrence grade 4.
- Bilateral OA-symptoms.
- Prior knee- or hip alloplasty.
- Glucocorticosteroid injection in the knee within the last 6 months.
- Inflammatory arthritis.
- Known neurotic disease such as multiple sclerosis or peripheral neuropathy.
- Prior myocardial infarct or apoplexy, or chest pain during physical activity.
- Other health related or medical conditions which makes it impossible participate in the study.
- Furthermore, it is an exclusion criterium in the following conditions where use of pneumatic occlusion would be considered contraindicated:
- Peripheral vascular disease
- Excessive varicose veins
- Prior history of deep venous thrombosis
- Venous insufficiency causing edema in the lower legs
- Systolic blood pressure over 160 mmHg or under 100 mmHg
Key Trial Info
Start Date :
January 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
February 14 2025
Estimated Enrollment :
96 Patients enrolled
Trial Details
Trial ID
NCT05437770
Start Date
January 1 2022
End Date
February 14 2025
Last Update
June 29 2025
Active Locations (1)
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1
Department of Physical and Occupational Therapy / Institute of Sports Medicine Copenhagen, Bispebjerg Hospital
Copenhagen, Denmark, 2400