Status:
UNKNOWN
Effects of Fucoidan on the Gut Microbiota in the Patients of Atopic Dermatitis
Lead Sponsor:
Chang Gung Memorial Hospital
Conditions:
Atopic Dermatitis
Eligibility:
All Genders
6-60 years
Phase:
NA
Brief Summary
Forty patients with physician-identified atopic dermatitis will be enrolled in the study. All patients must be aged between 6 and 60 years old. All patients consumed fucoidan for 3 months.
Detailed Description
Atopic dermatitis is an inflammatory disease with about 6-7% in Taiwan. Its clinical manifestations are repeated rashes and itching of the skin. The patient's skin is stimulated to release inflammator...
Eligibility Criteria
Inclusion
- Volunteer for study enrollment and sign inform consent
- The age of the patients must be between 6 and 60 years old. Both men and women can participate.
- Symptoms meet the diagnostic criteria of Hanifin and Rajka AD
- The severity of SCORAD (SCORing Atopic Dermatitis) is 25-50 points.
Exclusion
- Other eczema-like diseases that are not atopic dermatitis, such as contact dermatitis, seborrheic dermatitis, drug reactions, etc., shall be determined by a dermatologist.
- Associated with other skin diseases that may cause itching, as determined by a dermatologist.
- Have bacterial infection or are using oral or injectable western medicines such as steroids, antibiotics, leukotriene antagonists and other immunosuppressants; as well as using phototherapy, immunotherapy, hyposensitivity therapy; full month.
- Those who cannot cooperate with taking the medicine on time. Those who are unable to cooperate with filling out the questionnaire, drawing blood, and leaving stool samples.
- Those who have a history of allergy to fucoidan or have had adverse reactions and hyperthyroidism.
- Severe organ dysfunction, such as impaired renal and hepatic function at the time of initial diagnosis (including chronic kidney disease stage III, IV, V and AST, ALT ≥ 3 times the upper limit of normal), cirrhosis or heart failure, by clinician determination.
- Uncontrollable mental problems or other serious systemic diseases.
- Pregnant or breastfeeding women and all women of childbearing age who do not agree to take appropriate contraceptive measures.
Key Trial Info
Start Date :
October 4 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
March 6 2024
Estimated Enrollment :
40 Patients enrolled
Trial Details
Trial ID
NCT05437887
Start Date
October 4 2022
End Date
March 6 2024
Last Update
December 6 2022
Active Locations (1)
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1
Chang Gung Memorial Hospital
Taoyuan District, Taiwan