Status:
UNKNOWN
Diastolic Function Assessment With Cardiac Magnetic Resonance Imaging
Lead Sponsor:
Imperial College London
Conditions:
Diastolic Dysfunction
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Cardiac magnetic resonance (CMR) imaging is excellent at assessing the contractility of the heart muscle. However, relatively little is known about CMR's ability to assess the relaxation (diastolic fu...
Detailed Description
37 participants will be recruited, comprising a mix of patients with diastolic heart dysfunction and health controls. The diseased cohort will comprise patients with preserved systolic function and k...
Eligibility Criteria
Inclusion
- Cohort 1: patients with preserved systolic function, grade 2 or more diastolic dysfunction on echocardiography, a raised BNP, and a diagnosis typically causing HFPEF (e.g., hypertrophic cardiomyopathy, severe aortic stenosis, or cardiac amyloidosis).
- Cohort 2: patients without grade 2 or more diastolic dysfunction on echocardiography.
Exclusion
- Contraindications to CMR or echocardiographic scanning - for safety.
- Contraindications to gadolinium contrast agents - for safety.
- Severe claustrophobia - extra CMR scanning may prove too difficult.
- Pregnancy - likely to be undergoing progressive physiological changes in the conduct of the study which may invalid assumptions about repeat scanning.
- The ability to provide informed consent.
Key Trial Info
Start Date :
September 1 2022
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2024
Estimated Enrollment :
37 Patients enrolled
Trial Details
Trial ID
NCT05438030
Start Date
September 1 2022
End Date
June 1 2024
Last Update
March 2 2023
Active Locations (1)
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1
Hammersmith Hospital
London, United Kingdom, W12 0HS