Status:
COMPLETED
Electrical Intra-cutaneous Half-sine Stimulation for Optimized Preferential C-fiber Activation
Lead Sponsor:
University Hospital, Basel, Switzerland
Conditions:
Pain Perception
Secondary Hyperalgesia
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
This exploratory study is to improve an established pain model by a new stimulation profile that allows preferential activation of C fibers that are of main clinical interest in chronic pain and also ...
Detailed Description
Nociceptors in the epidermis are responsible for peripheral pain perception. Mechanical, thermal as well as chemical stimuli can trigger action potentials in nociceptors and thereby pain. Regarding pa...
Eligibility Criteria
Inclusion
- Healthy adults (18 - 65 years old, American Society of Anaesthesiologists (ASA) I or II)
- BMI between 18.5 until 25 kg/m2
- Able to understand the study and the NRS scale
- Able to give informed consent
Exclusion
- Regular intake of medications or drugs potentially interfering with pain sensation (analgesics, opioids, antihistamines, calcium and potassium channel blockers, serotonin / noradrenaline reuptake inhibitors, corticosteroids)
- Neuropathy
- Chronic pain
- Neuromuscular disease
- Dermatological disease as Atopic Dermatitis
- Psychiatric disease
- Pregnancy / Lactation
Key Trial Info
Start Date :
May 20 2022
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 25 2022
Estimated Enrollment :
24 Patients enrolled
Trial Details
Trial ID
NCT05440266
Start Date
May 20 2022
End Date
November 25 2022
Last Update
November 28 2023
Active Locations (1)
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1
Department of Anaesthesiology, University Hospital of Basel (USB)
Basel, Switzerland, 4031