Status:

COMPLETED

A Clinical Study of KLH-2109 in Uterine Fibroids Patient With Menorrhagia

Lead Sponsor:

Kissei Pharmaceutical Co., Ltd.

Conditions:

Uterine Fibroids (MeSH Heading: Leiomyoma)

Eligibility:

FEMALE

20+ years

Phase:

PHASE3

Brief Summary

Multi-center, randomized, double-blind, parallel-group study to confirm non-inferiority of KLH-2109 to Leuprorelin acetate in uterine fibroids patient with menorrhagia

Eligibility Criteria

Inclusion

  • Premenopausal Japanese woman diagnosed with uterine fibroids
  • Patients confirmed by transvaginal ultrasonography to have at least 1 myoma that meet all of the following conditions:
  • Larger than a certain standard
  • No calcification
  • Not receiving surgical treatment
  • Patients with a normal menstrual cycle
  • Patients diagnosed with menorrhagia

Exclusion

  • Patients with complication or history of blood system diseases (salasemia, sickle erythrocyte anemia, folic acid deficiency, coagulation disorder, etc.) (excluding iron deficiency anemia and latent iron deficiency anemia)
  • Patients with lower abdominal pain due to irritable bowel syndrome or lower abdominal pain due to severe interstitial cystitis
  • Patients with undiagnosed abnormal genital bleeding

Key Trial Info

Start Date :

October 11 2022

Trial Type :

INTERVENTIONAL

Allocation :

ACTUAL

End Date :

August 21 2024

Estimated Enrollment :

287 Patients enrolled

Trial Details

Trial ID

NCT05440383

Start Date

October 11 2022

End Date

August 21 2024

Last Update

March 14 2025

Active Locations (1)

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Clinical Resarch Site

Multiple Locations, Japan