Status:
NOT_YET_RECRUITING
tDCS for Cognitive Impairment Associated With Recent-onset Schizophrenia
Lead Sponsor:
University Hospital, Grenoble
Collaborating Sponsors:
Direction Générale de l'Offre de Soins
Conditions:
Schizophrenia
Psychotic Disorder
Eligibility:
All Genders
18-35 years
Phase:
NA
Brief Summary
Background: In parallel to the traditional symptomatology, deficits in cognition (memory, attention, reasoning, social functioning) contribute significantly to disability and suffering in individuals ...
Eligibility Criteria
Inclusion
- The inclusion criteria include:
- subjects of both genders, diagnosed with recent-onset schizophrenia (first 3 years of illness), confirmed through the Structured Clinical Interview for the American Psychiatric Association Diagnostic and Statistical Manual of Mental Disorders, 5th edition (SCID-5);
- aged 18-35 years;
- intelligence quotient (IQ) \> 55;
- cognitive deficit confirmed by a MCCB (MATRICS Cognitive Consensus Battery) total score T-score \< 40;
- the subjects should be receiving stable doses of antipsychotics for ≥ 4 weeks;
- the subjects are covered by a public health insurance.
- The exclusion criteria include:
- pregnant (controlled by urine pregnancy test in females of childbearing age) or breastfeeding women;
- unstable or acute medical conditions;
- subjects who receive involuntary treatment or guardianship;
- history of cranioencephalic trauma with loss of consciousness or central nervous system diseases that affect the brain;
- use of drugs that affect cognitive performance such as anticholinergic agents and benzodiazepines;
- current diagnosis of substance abuse or history of substance dependence in the last 6 months, except nicotine;
- MRI (Magnetic Resonance Imaging), PET (Positron Emission Tomography) or tDCS (transcranial Direct Current Stimulation) contraindications
Exclusion
Key Trial Info
Start Date :
June 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 1 2027
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05440955
Start Date
June 1 2023
End Date
June 1 2027
Last Update
April 4 2023
Active Locations (4)
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1
CHU Grenoble Alpes
La Tronche, Auvergne-Rhône-Alpes, France, 38700
2
CH Alpes-Isère
Saint-Égrève, Auvergne-Rhône-Alpes, France, 38120
3
CH Le Vinatier
Bron, France, 69500
4
CHU Saint-Etienne
Saint-Etienne, France, 42055