Inclusion Criteria:

• Adult participants ≥ 18 years old at the time of signing the informed consent form.
• Patients hospitalised with viral lung infection.
• Hypoxaemia requiring treatment with supplemental O2.

Hypoxaemia is defined as:

SpO2 ≤ 90% OR

SpO2 ≤ 92% AND one or both of the following:

Radiographic infiltrates by CXR/CT compatible with viral lung infection per investigator judgement.

Use of accessory muscles of respiration or RR (respiratory rate) > 22.

- Patient remains hypoxaemic at randomisation requiring treatment with supplemental oxygen.

Exclusion Criteria:

• Known fungal or parasitic lung infection, aspiration lung infection, lung abscess, or evidence of septic shock. Bacterial co-infection is allowed, unless, in the opinion of the investigator, bacterial infection defines the severity of the participant's condition.
• Hypoxaemia caused primarily by extrapulmonary insult or by lung injury of non-infective aetiology.
• Ongoing IMV/ECMO at randomisation.