Status:
RECRUITING
RItuximab Versus Ocrelizumab in Relapsing-remitting Multiple Sclerosis.
Lead Sponsor:
Rennes University Hospital
Conditions:
Multiple Sclerosis
Relapsing-remitting Multiple Sclerosis
Eligibility:
All Genders
18-55 years
Phase:
PHASE3
Brief Summary
The goal of this randomized clinical trial is to compare relapse remitting multiple sclerosis (RRMS) patients treated by ocrelizumab or by rituximab followed for 2 years. The main question it aims to ...
Detailed Description
Multiple sclerosis (MS) is an autoimmune inflammatory disease of the central nervous system (CNS). This disease is the leading cause of non-traumatic disability in young adults and France is character...
Eligibility Criteria
Inclusion
- Inclusion Criteria:
- Patients presenting a relapsing remitting MS according to Mac Donald 2017 criteria, with clinical or radiological criteria of activity (ie at least one relapse AND/OR one new T2 lesion in the last 12 months before inclusion);
- Age between 18 and 55 years
- EDSS ≤ 5
- Brain MRI within 6 months before inclusion
- For women of childbearing potential\*: effective contraception (effective contraception include oral contraception, intrauterine devices and other forms of contraception with failure rate \<1%, for the duration of the study and until 12 months after last dose administered) \* A woman is considered of childbearing potential (WOCBP), i.e. fertile, following menarche and until becoming post-menopausal unless permanently sterile. Permanent sterilisation methods include hysterectomy, bilateral salpingectomy and bilateral oophorectomy.
- A postmenopausal state is defined as no menses for 12 months without an alternative medical cause. A high follicle stimulating hormone (FSH) level in the postmenopausal range may be used to confirm a post-menopausal state in women not using hormonal contraception or hormonal replacement therapy. However, in the absence of 12 months of amenorrhea, a single FSH measurement is insufficient.
- Having signed an informed consent form
- Patients covered with social insurance
- Non-Inclusion Criteria:
- Secondary or primary progressive MS;
- Previous treatment by mitoxantrone, cladribine, alemtuzumab and anti CD20 therapies in the last two years;
- Previous treatment by fingolimod or natalizumab in the last 4 weeks;
- Treatment with high dose corticosteroids during the 30 days preceding the inclusion;
- Occurrence of a relapse less than 30 days before inclusion;
- Pregnancy or breastfeeding;
- Other neurologic or systemic disease;
- Concomitant participation or Participation in another therapeutic trial in the last 6 months;
- Incapacity to understand or sign the consent form;
- Contraindication to MRI;
- Contraindication to anti-CD20 therapies:
- Receipt of a live or live-attenuated vaccine within 6 weeks prior to randomization
- Active malignancy.
- Any ongoing infection
- Severe heart failure (New York Heart Association Class IV) or severe uncontrolled cardiac disease
- Positive test for HIV, hepatitis B or C, or tuberculosis
- Severe immune deficiency:
- Lymphopenia grade 3 (0.2 to 0.5 × 10\^9/L) or higher grades
- Neutropenia grade 3 (0.5 to 1.0 × 10\^9/L) or higher grades
- Known hypersensitivity or other known side effects for any of the study medications, including co-medications such as high glucocorticosteroids
- AST or ALT \>=3ULN
- Platelet (thrombocyte) count \< 100 x 10\^9/L
- Adults legally protected (under judicial protection, guardianship, or supervision), persons deprived of their liberty.
Exclusion
Key Trial Info
Start Date :
June 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2030
Estimated Enrollment :
386 Patients enrolled
Trial Details
Trial ID
NCT05758831
Start Date
June 1 2023
End Date
May 1 2030
Last Update
February 2 2026
Active Locations (23)
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1
Hospices Civils de Lyon Hôpital Neurologique Pierre Wertheimer
Lyon, Bron, France, 69677
2
CHRU de Brest - Hôpital la Cavale Blanche
Brest, France, 29609
3
Centre Hospitalier Universitaire de Caen
Caen, France, 14033
4
Centre Hospitalier de Pontoise - GHT NOVO
Cergy-Pontoise, France, 95300