Status:

RECRUITING

A Study of Magnesium and Bladder Spasms Following Ambulatory Urologic Procedures

Lead Sponsor:

Mayo Clinic

Conditions:

Bladder Spasms

Eligibility:

All Genders

18+ years

Phase:

PHASE2

Brief Summary

This research is being done to find out whether intravenous magnesium is effective in the treatment of bladder spasms after urologic surgery.

Eligibility Criteria

Inclusion Criteria:

- Be undergoing a bladder invasive procedure with or without planned urinary catheter on Mayo Clinic Gonda 7 Outpatient Procedure Center.

Exclusion Criteria:

  • Are unable to grant informed consent or comply with study procedure.
  • Allergy or known sensitivity to magnesium or Renacidin.
  • Expected or high risk of bladder extravasation.
  • Ongoing atrial fibrillation prior to surgery.
  • Are undergoing emergency surgery.
  • Are pregnant.
  • Known hypermagnesemia.
  • Patients with neuromuscular weakness (e.g., Myasthenia gravis) due to magnesium's muscle weakening effect.
  • Patients with myocardial compromise or cardiac conduction defects because of magnesium's anti-inotropic effects.
  • Patients with renal insufficiency, glomerular filtration rate less than 30, since Magnesium is eliminated by the kidneys resulting in exaggerated rise in serum magnesium.
  • Patients with concomitant use of a calcium channel blocker since magnesium sulfate could act synergistically to suppress muscular contractility.

Key Trial Info

Start Date :

July 31 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2026

Estimated Enrollment :

120 Patients enrolled

Trial Details

Trial ID

NCT05806996

Start Date

July 31 2023

End Date

December 31 2026

Last Update

May 13 2025

Active Locations (1)

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Mayo Clinic in Minnesota

Rochester, Minnesota, United States, 55905