Status:
RECRUITING
Determination of the Clonality Profile in Myeloproliferative Neoplasms and Association With the Thrombotic Complications (CLOJAK)
Lead Sponsor:
University Hospital, Bordeaux
Conditions:
Myeloproliferative Neoplasm
Eligibility:
All Genders
18+ years
Brief Summary
Myeloproliferative Neoplasms (MPN) are associated with an increased risk of thrombosis. Platelets, red blood cells (RBC), leukocytes and endothelial cells are involved in these complications. An assoc...
Detailed Description
Myeloproliferative Neoplasms (MPN) are hematological malignancies associated with an increased risk of thrombosis. Although different cell types have been involved in these complications (platelets, r...
Eligibility Criteria
Inclusion Criteria:
- Adult patient (age ≥ 18 years)
- Inclusion at diagnosis or during the year following the diagnosis of PV or ET (2016 WHO criteria except bone marrow biopsy that is optional), before introduction of a cytoreductive treatment
- Patient carrying a JAK2V617F mutation
- Subject registered with a social security scheme
- Written informed consent obtained
- Acceptance of inclusion in the FIMBANK registry (specific consent form needed)
Exclusion Criteria:
- ET or PV Patient not carrying a JAK2V617F mutation
- Patient with cytoreductive treatment (hydroxyurea, anagrelide, interferon, ruxolitinib or other chemotherapy) at the time of blood sampling
- Person under judicial safeguards, trustee or curatorship
- Person unable to give her consent
- Non-cooperative person
- Exclusion period after another clinical study or participation to another clinical study in the 30 days before inclusion
Key Trial Info
Start Date :
June 19 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 1 2025
Estimated Enrollment :
120 Patients enrolled
Trial Details
Trial ID
NCT05839717
Start Date
June 19 2023
End Date
December 1 2025
Last Update
December 17 2024
Active Locations (11)
Enter a location and click search to find clinical trials sorted by distance.
1
CHU d'Angers, Service Maladies du Sang
Angers, France, 49933
2
CH de Bayonne, Service Hématologie Clinique
Bayonne, France, 64100
3
CHU de Bordeaux, Service Médecine Interne et Maladies Infectieuses
Bordeaux, France, 33000
4
Institut Bergonié, Service Hématologie Clinique
Bordeaux, France, 33000