Status:
COMPLETED
Nitrate Modulates Cognitive Impairment Via Oral Microbiota.
Lead Sponsor:
Peking University Sixth Hospital
Conditions:
Microtia
Alcohol Dependence
Eligibility:
MALE
18-60 years
Phase:
NA
Brief Summary
Alcohol use is increasingly prevalent in modern society and is known to cause cognitive impairment and dysregulation of inflammatory responses. In the present study, the investigators want to perform ...
Eligibility Criteria
Inclusion
- Han nationality
- Montreal Cognitive Assessment(MoCA) score \>11
- Diagnosis of alcohol dependence
Exclusion
- Past or current infectious disease
- Past or current heart, brain, liver, kidney, and other severe diseases
- Past or current metabolic diseases that can lead to abnormalities of the immune system, such as obesity (Body Mass Index \> 30 kg/m2), diabetes, or rheumatoid arthritis
- Past or current neurodegenerative diseases, such as Parkinson's disease
- Use of steroidal and non-steroidal anti-inflammatory drugs, antibiotics, antioxidants, and immunosuppressive agents within two months of enrollment
- Use of probiotics and probiotics every day for the first two months before enrollment
- Previous or current DSM-IV diagnosis of schizophrenia, depression, anxiety disorder, bipolar disorder, mental retardation, dementia (excluding mild cognitive impairment, MCI), or substance dependence other than alcohol and nicotine
- Irregular eating habits that affect the oral flora (except alcohol) in the previous two months
- Current oral disease
Key Trial Info
Start Date :
September 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
August 7 2024
Estimated Enrollment :
70 Patients enrolled
Trial Details
Trial ID
NCT05963659
Start Date
September 10 2023
End Date
August 7 2024
Last Update
June 3 2025
Active Locations (1)
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1
Anhui mental health center
Hefei, Anhui, China, 230022