Status:
UNKNOWN
Temporal Diffusion Spectroscopy MRI in Predicting the CPS of PD-L1 Expression and the Efficacy of Neoadjuvant Therapy
Lead Sponsor:
Sun Yat-Sen Memorial Hospital of Sun Yat-Sen University
Conditions:
Head and Neck Squamous Cell Carcinoma
Magnetic Resonance Imaging
Eligibility:
All Genders
Brief Summary
The goal of this observational study is to explore the application of temporal diffusion spectroscopy MRI in head and neck squamous cell carcinoma (HNSCC). The main questions it aims to answer are: ...
Eligibility Criteria
Inclusion
- Patients first diagnosed with head and neck squamous cell carcinoma (HNSCC) by pathological biopsy
- Patients proposed to receive 2-3 courses of neoadjuvant chemotherapy and immunotherapy
- Patients without contraindications for MRI, such as nonremovable ferromagnetic metal foreign body, claustrophobia, renal insufficiency, and previous history of gadolinium contrast allergy
Exclusion
- Less than 10mm in the maximum diameter of the baseline primary tumor
- Poor MRI image quality with obvious metal or motion artifacts
- The failure to complete the course of neoadjuvant therapy
Key Trial Info
Start Date :
July 1 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
December 31 2025
Estimated Enrollment :
136 Patients enrolled
Trial Details
Trial ID
NCT05964595
Start Date
July 1 2023
End Date
December 31 2025
Last Update
July 28 2023
Active Locations (1)
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1
Sun Yat-sen Memorial Hospital
Guangzhou, Guangdong, China, 510000