Status:
RECRUITING
High-Intensity Exercise to Combat Vascular and Cognitive Dysfunction in Adults With HIV
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
HIV
Arterial Stiffness
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whet...
Detailed Description
This is a single site, randomized exercise trial with individuals at least 50 years of age living with HIV who experience suboptimal cognition. The overall goals of this proposal are to determine whet...
Eligibility Criteria
Inclusion
- Age 50 years and older
- Sedentary lifestyle, defined as \< 150 min/wk moderate physical activity as assessed by CHAMPS questionnaire
- Neurocognitive Impairment (as assessed using the BRACE+
- Prescribed HIV ART for ≥ 12 months, with no current use of older drugs with established mitochondrial toxicity
- Able to speak, read, and write in English
- Willingness to participate in all study procedures
Exclusion
- Diagnosis of mitochondrial disease
- Active substance abuse or factors preventing compliance or safety
- Uncontrolled hypertension, defined as resting BP \> 150/90 mmHG
- Chronic kidney disease
- Severe cardiac disease, including NYHA Class III or IV congestive heart failure, clinically significant aortic stenosis, history of cardiac arrest, use of a cardiac defibrillator, or uncontrolled angina
- Acute myocardial infarction identified by medical history and ECG
- Pulmonary disease requiring the use of supplemental oxygen
- Poorly controlled diabetes
- Neuropsychologically Intact
- Orthopedic problems that limit ability to perform exercise
- Simultaneous participation in another intervention trial
Key Trial Info
Start Date :
February 5 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2028
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05965518
Start Date
February 5 2024
End Date
December 1 2028
Last Update
August 8 2025
Active Locations (1)
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1
University of Alabama at Birmingham
Birmingham, Alabama, United States, 35205