Status:
RECRUITING
Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
Lead Sponsor:
University of Texas Southwestern Medical Center
Collaborating Sponsors:
The University of Texas at Arlington
National Institute of Mental Health (NIMH)
Conditions:
Major Depressive Disorder (MDD)
Healthy Adult Volunteer
Eligibility:
All Genders
21-80 years
Brief Summary
This is a cross-sectional pilot study designed to establish hot and cold cognitive functions and underlying neurocircuitry in older adults with MDD. The investigators will study 120 participants aged ...
Detailed Description
Major depressive disorder (MDD) is a common, chronic, and disabling disorder that affects individuals across the lifespan. Research has consistently found that a core domain of MDD is cognitive dysfun...
Eligibility Criteria
Inclusion
- Male and female participants
- Age between 21-80 years old
- DSM-5 diagnosis of major depressive disorder (MDD) based on Mini Neuropsychiatric Interview
- Inventory of Depressive Symptomatology-Clinician Rated version (IDS-C) total score \> 14
- Able to read, write, and comprehend English
- Provide informed consent; willing to comply with study protocol
Exclusion
- History of bipolar disorder, schizophrenia, or schizoaffective disorder
- Presence of psychotic features
- Lifetime central nervous system (CNS) disease (including head injury with loss of consciousness \> 5 minutes)
- History of neurodevelopmental disorder (e.g., Autism spectrum disorder)
- History of medical conditions that can affect neurocognitive function as well as be confounded with age (e.g., thyroid disease, endocrine illnesses)
- Women who are pregnant
- Current use of medications with known impacts on neurocognitive function (e.g., acetylcholinesterase inhibitors, amphetamine, methylphenidate, vortioxetine, sedatives)
- Alcohol/substance use disorder within past 3 months
- DSM-5 diagnosis of major cognitive impairment
- Current sensory or physical impairment that interferes with testing.
- Contraindication to MRI and MEG (only for depressed participants) (e.g., any electronic / metallic implants near or within the head or body, claustrophobia)
Key Trial Info
Start Date :
December 11 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 31 2026
Estimated Enrollment :
276 Patients enrolled
Trial Details
Trial ID
NCT05966532
Start Date
December 11 2023
End Date
August 31 2026
Last Update
December 15 2025
Active Locations (2)
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1
University of Texas Arlington
Arlington, Texas, United States, 76010
2
University of Texas Southwestern Medical Center
Dallas, Texas, United States, 75390-9127