Status:
COMPLETED
Social Safety Learning in the Brain Oxytocin System
Lead Sponsor:
University of Washington
Conditions:
Social Phobia
Eligibility:
All Genders
18-45 years
Phase:
PHASE2
Brief Summary
The investigators are conducting this research study to examine whether oxytocin enhances social safety learning (learning safety through the experience of another individual) in people with social an...
Detailed Description
The goal of the current study is to examine the potential role of oxytocin in enhancing social learning in SAD. The investigators' primary hypothesis is that vicarious extinction learning will contrib...
Eligibility Criteria
Inclusion
- For Clinical Sample
- Men and women age 18-45
- Women must be having regular menstrual cycles and not be taking oral contraception
- Primary diagnosis of social anxiety disorder
- For Healthy Sample
- Men and women age 18-45
- Women must be having regular menstrual cycles and not be taking oral contraception
- No current or lifetime history of psychiatric, neurological, or medical disorders
Exclusion
- For All Groups
- Pregnancy or breastfeeding
- Positive urine drug screening test result
- History of nasal pathology
- Current use of any psychotropic medication or steroids
- Active substance use disorder within the past 6 months
- History of serious medical illnesses or untreated endocrine diseases
- History of head injury, neurological disorder, or neurosurgical procedure
- Positive magnetic resonance (MR) screen
- For Clinical Sample
- Lifetime diagnoses of mania or psychotic disorder based on the Diagnostic and Statistical Manual (DSM- 5th ed)
- Acute suicidal ideation
- For Healthy Sample
- Lifetime DSM-5 diagnosis of any medical, neurological, or psychiatric illness
Key Trial Info
Start Date :
June 26 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
September 30 2024
Estimated Enrollment :
121 Patients enrolled
Trial Details
Trial ID
NCT05968651
Start Date
June 26 2023
End Date
September 30 2024
Last Update
December 13 2024
Active Locations (1)
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1
University of Washington
Seattle, Washington, United States, 98195