Status:

UNKNOWN

Improvement Effect of Lacosamide and Levetiracetam on Cognitive in Alzheimer's Disease Patients With Epilepsy

Lead Sponsor:

Xiangya Hospital of Central South University

Conditions:

Alzheimer Disease 3

Epilepsy

Eligibility:

All Genders

18-80 years

Phase:

PHASE4

Brief Summary

Participants will perform Mini-Mental State Examination (MMSE), Montreal Cognitive Assessment (MoCA), Clinical Dementia Rating (CDR), Alzheimer's disease assessment scale-cognitive section (ADAS-Cog),...

Eligibility Criteria

Inclusion

  • Clinically diagnosed as Alzheimer's disease and treated with cholinesterase inhibitors;
  • New seizures or subclinical epileptic discharges;
  • Mini-Mental State Examination score ≥ 18 points, and/or Clinical Dementia Rating (CDR) score \< 2 points;
  • Sign the informed consent form.

Exclusion

  • Suffering from syncope, transient ischemic attack, hysteria attack, migraine and other transient brain dysfunction;
  • Serious medical disease (especially atrioventricular block) or mental illness;
  • There are structural abnormalities related to epilepsy in other brain regions of imaging

Key Trial Info

Start Date :

July 5 2023

Trial Type :

INTERVENTIONAL

Allocation :

ESTIMATED

End Date :

December 31 2025

Estimated Enrollment :

140 Patients enrolled

Trial Details

Trial ID

NCT05969054

Start Date

July 5 2023

End Date

December 31 2025

Last Update

August 4 2023

Active Locations (1)

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Xiangya Hospital of Central South University

Changsha, Hunan, China, 410008