Status:
RECRUITING
The Molecular Basis of Inherited Reproductive Disorders
Lead Sponsor:
Stephanie B. Seminara, MD
Conditions:
Hypogonadotropic Hypogonadism
Reproductive Disorder
Eligibility:
All Genders
1+ years
Brief Summary
The goal of this study is to learn more about the genes that control puberty and reproduction in humans.
Detailed Description
All study subjects will undergo the same activities. Subjects will provide up to five tubes of blood for genetic analysis, complete a smell test, and answer questions about their health and family his...
Eligibility Criteria
Inclusion
- Participants must belong to one of the following categories:
- Failure to go through a normal, age-appropriate, spontaneous puberty and low sex steroid levels in the setting of low/normal gonadotropins or,
- Abnormally early development of puberty or,
- Normal puberty with subsequent development of low gonadotropin levels or,
- Evidence of a reproductive disorder with high gonadotropin levels or,
- Pre-pubertal individuals with features suggestive of hypogonadotropic hypogonadism or,
- Affected and unaffected family members of individuals that fit criteria above
Exclusion
Key Trial Info
Start Date :
January 21 2021
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
March 1 2026
Estimated Enrollment :
600 Patients enrolled
Trial Details
Trial ID
NCT05971836
Start Date
January 21 2021
End Date
March 1 2026
Last Update
July 25 2025
Active Locations (1)
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1
Massachusetts General Hospital
Boston, Massachusetts, United States, 02114