Status:
COMPLETED
INulin-type Fructans-induced Gut Microbiota Modulation Impact on GUT-SKIN Axis Parameters in Psoriasis
Lead Sponsor:
Polish Academy of Sciences
Collaborating Sponsors:
University of Warmia and Mazury
Warsaw University of Life Sciences
Conditions:
Psoriasis
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
There is increasing evidence of a strong, bidirectional correlation between the gut and the skin, that associates gastrointestinal health with skin homeostasis and allostasis. The dysregulation in the...
Detailed Description
The gut microbiota contributes to the health of the host. It enables the digestion of food, the proper functioning of the immune system, and protection against the invasion of pathogens. The gut micro...
Eligibility Criteria
Inclusion
- Inclusion Criteria for PS patients:
- mild psoriasis (PASI \< 10),
- omnivorous diet,
- body mass index (BMI) 18 - 30 kg/m2
- general good health
- willing to give the written informed consent to participate the study
- Exclusion Criteria for PS patients:
- other chronic or acute inflammatory skin diseases,
- gastrointestinal disease, cancer, cardiovascular complications, heart, kidney, and liver failure,
- bad or average overall health,
- positive tTG antibodies,
- currently receive anti-psoriatic systemic and biologic treatment,
- received antibiotics within previous month,
- use of dietary supplements containing probiotic, prebiotic, and/or symbiotic within previous month,
- Pregnancy, lactation
Exclusion
Key Trial Info
Start Date :
February 2 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 28 2024
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT05971992
Start Date
February 2 2023
End Date
June 28 2024
Last Update
July 10 2025
Active Locations (2)
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1
Chair and Clinic of Dermatology, Sexually Transmitted Diseases and Clinical Immunology, Municipal Hospital Complex, al. Wojska Polskiego 30
Olsztyn, Poland, 10-229
2
Institute of Animal Reproduction and Food Research, Polish Academy of Sciences, ul. Tuwima 10
Olsztyn, Poland, 10-748