Status:
RECRUITING
Cardiac RadiothErapy for VEntricular Tachycardia
Lead Sponsor:
Universitaire Ziekenhuizen KU Leuven
Conditions:
Ventricular Tachycardia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
Objective: To explore in our center the feasibility and safety of a SBRT treatment method for VT. Study population: Patients with ventricular tachycardia that are refractory to dose-escalated antiarr...
Eligibility Criteria
Inclusion
- Patient ≥ 18 years
- Presence of a structural heart disease and an implantable cardioverter defibrillator (ICD)
- Documented sustained monomorphic VT that requires ICD intervention (e.g., shock or anti-tachycardia stimulation)
- The VT is inducible by ICD via non-invasive programmed stimulation (NIPS) or during electrophysiology measurement
- Patient must have failed or become intolerant to at least one antiarrhythmic medication
- Patient must have failed at least one invasive catheter ablation procedure, or have a contraindication to a catheter ablation procedure, or have VT thought to arise from a protected location
- Ability to give a written informed consent and willingness to return for follow-up
Exclusion
- Pregnancy or breastfeeding
- Lack of evidence of a myocardial scar triggering the VT
- Polymorphic VT or ventricular fibrillation (VF) as a clinical heart rhythm
- Advanced symptomatic heart failure defined as NYHA Class IV heart failure
- Previous radiotherapy with cardiac involvement
- Life expectancy \< 6 months, in the absence of VT, as best based on clinical judgment by the treating and enrolling physicians
- Any condition that is deemed a contraindication in the judgment of the investigators
Key Trial Info
Start Date :
May 23 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
5 Patients enrolled
Trial Details
Trial ID
NCT05973578
Start Date
May 23 2023
End Date
May 1 2026
Last Update
August 3 2023
Active Locations (1)
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1
UZ Leuven
Leuven, Belgium, 3000