Status:
RECRUITING
Reducing Empiric VAncomycin Use in Pediatric Suspected Sepsis
Lead Sponsor:
Children's Hospital of Philadelphia
Collaborating Sponsors:
Children's Healthcare of Atlanta
St. Louis Children's Hospital
Conditions:
Sepsis
Sepsis Mrsa
Eligibility:
All Genders
Phase:
NA
Brief Summary
The goal of this quasi-experimental interventional study is to determine the effectiveness of a multifaceted stewardship intervention in reducing overall vancomycin use in five tertiary care Pediatric...
Detailed Description
Vancomycin is among the most commonly prescribed antibiotics in United States children's hospitals, and inappropriate use of vancomycin is common. Given the high prevalence of acute kidney injury asso...
Eligibility Criteria
Inclusion
- Patient
- Admitted to one of the participating PICUs during the study period
- Patient
Exclusion
- None
- Clinician Inclusion Criteria:
- PICU prescribing clinician (including attending physicians, fellows, residents, nurse practitioners, and physician assistants) OR sepsis stakeholder (leader of sepsis quality improvement work, medical director) at one of the participating sites at the time the survey is deployed
- Age ≥ 18 years old
- Employed by one of the participating sites
- Clinician
Key Trial Info
Start Date :
August 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
May 1 2026
Estimated Enrollment :
52500 Patients enrolled
Trial Details
Trial ID
NCT05975671
Start Date
August 21 2023
End Date
May 1 2026
Last Update
September 19 2025
Active Locations (4)
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1
Children's Healthcare of Atlanta
Atlanta, Georgia, United States, 30322
2
Johns Hopkins Children's Center
Baltimore, Maryland, United States, 21287
3
St. Louis Children's Hospital
St Louis, Missouri, United States, 63110
4
Children's Hospital of Philadelphia
Philadelphia, Pennsylvania, United States, 19146