Status:
UNKNOWN
Skin Sodium and Salt Sensitivity of Blood Pressure
Lead Sponsor:
Cambridge University Hospitals NHS Foundation Trust
Collaborating Sponsors:
King's College London
Conditions:
Hypertension
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Eating too much salt raises blood pressure and the risk of having a heart attack or stroke. The investigators do not fully understand why salt raises blood pressure, but storage of sodium in the body,...
Detailed Description
The physiological basis of salt sensitivity of blood pressure (SSBP) is poorly understood, and determining which patients have SSBP is not straightforward. Furthermore, determining salt sensitivity re...
Eligibility Criteria
Inclusion
- Have given written informed consent to participate
- Aged 18 or above
- Be hypertensive defined as:
- Currently untreated with an ABPM day time average blood pressure or average home blood pressure of ≥135 mmHg (systolic) or ≥85 mmHg (diastolic)
- OR
- Patients who are taking antihypertensive drugs at sub therapeutic doses or in ineffective combinations, and who are felt likely to be controllable on a study drug and willing and able to be washed out, at the discretion of the CI/PI, can enter the study if they meet the above criteria.
Exclusion
- Uncontrolled blood pressure ≥ 180/110mmHg
- Known or suspected secondary hypertension
- Pregnant or breastfeeding women
- Significant sensitivity or contraindications to any of the study medications
- Participants taking lithium or are regularly consuming non-steroidal anti-inflammatory drugs at variable doses
- Requirement to take any of the study drugs continuously e.g. ACEi and heart failure
- Any clinically significant hepatic impairment
- Any clinically significant kidney impairment
- Concurrent participation in another clinical trial or study using systemic vasoactive medications or medications known to interact with the study drugs
- Patients who are deemed unsuitable by the investigator on clinical grounds e.g. an abnormal heart rhythm due to Atrial Fibrillation (AF)
Key Trial Info
Start Date :
August 1 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 1 2024
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05976438
Start Date
August 1 2023
End Date
December 1 2024
Last Update
August 4 2023
Active Locations (2)
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1
Addenbrooke's Hospital
Cambridge, United Kingdom
2
St Thomas' Hospital
London, United Kingdom