Status:
ENROLLING_BY_INVITATION
Home-based tDCS in Frontotemporal Dementia or Alzheimer's Disease
Lead Sponsor:
Johns Hopkins University
Collaborating Sponsors:
Ybrain Inc.
National Institute on Deafness and Other Communication Disorders (NIDCD)
Conditions:
Mild Cognitive Impairment
Primary Progressive Aphasia
Eligibility:
All Genders
50-90 years
Phase:
NA
Brief Summary
The primary objective of this research is to evaluate the effects of non-invasive brain stimulation and computerized cognitive training on executive functioning in individuals with Primary Progressive...
Detailed Description
In this within-subject cross-over protocol, all participants will receive both, cognitive training and brain stimulation tDCS. Participants will be randomly assigned to begin with either cognitive tra...
Eligibility Criteria
Inclusion
- Must be clinically diagnosed with PPA, fronto-temporal dementia (FTD), MCI or mild Alzheimer's disease (AD). Diagnosis will be based on neuropsychological testing, language testing (most commonly the Western Aphasia Battery), MRI, and clinical assessment.
- Must be right-handed.
- Must be proficient in English.
- Must have a minimum high-school education.
Exclusion
- Uncorrected visual or hearing impairment by self-report.
- Stroke/other premorbid neurological disorder affecting the brain.
- Any other developmental language-based learning disorder other than PPA.
- Inability to follow directions for baseline tasks.
- Pre-existing psychiatric disorders such as behavioral disturbances, severe depression, and schizophrenia that do not allow them to comply or follow the study schedule and requirements such as repeated evaluation and therapy will be excluded.
- Exclusion Criteria for MRI participation:
- Severe claustrophobia.
- Cardiac pacemakers or ferromagnetic implants.
- Pregnant women.
Key Trial Info
Start Date :
August 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
October 10 2025
Estimated Enrollment :
50 Patients enrolled
Trial Details
Trial ID
NCT05978804
Start Date
August 10 2023
End Date
October 10 2025
Last Update
August 20 2025
Active Locations (1)
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1
Johns Hopkins University
Baltimore, Maryland, United States, 21287