Status:
RECRUITING
Omental Tissue Autograft in Human Recurrent Glioblastoma Multiforme (rGBM)
Lead Sponsor:
Northwell Health
Conditions:
Glioma
Glioma, Malignant
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
This single center, single arm, open-label, phase I study will assess the safety of laparoscopically harvested autologous omentum, implanted into the resection cavity of recurrent glioblastoma multifo...
Detailed Description
Laparoscopically harvested omental grafts are commonly used to fill surgical cavities after resection of head and neck cancers. Investigators hypothesize that an omental tissue graft implanted into ou...
Eligibility Criteria
Inclusion
- Subject is a male or female 18 years of age or older.
- Subject is undergoing planned resection of known or suspected GBM.
- Subject has a Karnofsky Performance Status (KPS) 70% or greater.
- Subject has a life expectancy of at least 6 months, in the opinion of the Investigator.
- Based on the pre-operative evaluation by neurosurgeon, the subject is a candidate for ≥ 80% resection of enhancing region.
- Subject must be able to undergo MRI evaluation.
- Subject meets the following laboratory criteria:
- White blood count ≥ 3,000/μL
- Absolute neutrophil count ≥ 1,500/μL
- Platelets ≥ 100,000/μL
- Hemoglobin \> 10.0 g/dL (transfusion and/or ESA allowed)
- Total bilirubin and alkaline phosphatase ≤ 2x institutional upper limit of normal (ULN)
- Aspartate aminotransferase (AST) and alanine aminotransferase (ALT) \< 3 x ULN
- Blood urea nitrogen (BUN) and creatinine \< 1.5 x ULN
- Females of reproductive potential must have a negative serum pregnancy test and be willing to use an acceptable method of birth control.
- Able to understand and willing to sign an institutional review board (IRB)- approved written informed consent document
- Inclusion criteria considered during surgery:
- Subject has a histologically confirmed (frozen section) diagnosis of recurrent WHO Grade IV glioblastoma multiforme (GBM).
- Omental graft is technically feasible.
Exclusion
- Subject, if female, is pregnant or is breast feeding.
- Subject intends to participate in another clinical trial.
- Subject intends to undergo treatment with the Gliadel® wafer at the time of this surgery.
- Subject has an active infection requiring treatment.
- Subject has radiographic evidence of multi-focal disease or leptomeningeal dissemination.
- Subject has a history of other malignancy, unless the patient has been disease- free for at least 5 years. Adequately treated basal cell carcinoma or squamous cell skin cancer is acceptable regardless of time, as well as localized prostate carcinoma or cervical carcinoma in situ after curative treatment
- Subject has a known positive test for human immunodeficiency virus infection, or active hepatitis B or hepatitis C infection.
- Subject has a history or evidence of any other clinically significant disorder, condition or disease that would pose a risk to subject safety or interfere with the study evaluation, procedures or completion.
- Subject has had prior abdominal surgery.
- Subject has severe renal insufficiency rendering gadolinium MRI contraindicated.
- Subject who are unable to have an MRI scan for any reason.
Key Trial Info
Start Date :
April 4 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2027
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05979064
Start Date
April 4 2023
End Date
April 1 2027
Last Update
September 19 2024
Active Locations (1)
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1
Lenox Hill Brain Tumor Center
New York, New York, United States, 10075