Status:
COMPLETED
Comparing Chemoprevention Drugs for School-based Malaria Control
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
Kamuzu University of Health Sciences
Doris Duke Charitable Foundation
Conditions:
Malaria,Falciparum
Anemia in Children
Eligibility:
All Genders
6+ years
Phase:
PHASE4
Brief Summary
This is an individually randomized, controlled, single blind three arm clinical trial of malaria chemoprevention strategies Arm 1: Intermittent preventive treatment with dihydroartemisinin-piperaquine...
Detailed Description
Students attending a single primary school in Machinga District, Malawi who were enrolled in NCT05244954 were offered enrollment in this follow-on study. The intervention will be conducted every 6-wee...
Eligibility Criteria
Inclusion
- Students (enrolled in the primary intervention)
- Previously enrolled in NCT05244954
- Currently enrolled in the study school
- Plan to attend the study school for the remainder of the school year
- Parent/guardian available to provide written informed consent Younger children in participant households (enrolled in the Household Prevalence survey)
- Slept in the household for most nights in the last month
- Age 6-59 months
- Parent/guardian available to provide written informed consent
Exclusion
- Students (enrolled in the primary intervention)
- Current evidence of severe malaria or danger signs
- Known adverse reaction to the study drugs
- History of cardiac problems or fainting
- Taking medications known to prolong QT
- Family history of prolonged QT
- Taking trimethoprim-sulfamethoxazole aka Bactrim or Cotrimoxazole
- Epilepsy
- Psoriasis Household members (enrolled in the Household Prevalence survey)
- Household with more than one school-age child enrolled in the study
- Current evidence of severe malaria or danger signs
Key Trial Info
Start Date :
February 13 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
July 28 2023
Estimated Enrollment :
646 Patients enrolled
Trial Details
Trial ID
NCT05980156
Start Date
February 13 2023
End Date
July 28 2023
Last Update
August 7 2023
Active Locations (1)
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1
Kamuzu University of Health Sciences
Blantyre, Malawi