Status:
UNKNOWN
Fecal Microbiota Transplantation for Decolonization of Carbapenem-resistant Enterobacteriaceae
Lead Sponsor:
The University of Hong Kong
Conditions:
Carbapenem-Resistant Enterobacteriaceae Infection
Fecal Microbiota Transplantation
Eligibility:
All Genders
18-90 years
Phase:
NA
Brief Summary
The emergence of multidrug-resistant organisms (MDROs) has become one of the major threats to the healthcare system in Hong Kong in recent years. The situation is particularly worrisome for carbapenem...
Detailed Description
CRE colonization is associated with a 16.5% risk of infection with a 10% mortality rate. CRE also poses a tremendous strain on the healthcare cost as well as the medical/nursing manpower. The hospital...
Eligibility Criteria
Inclusion
- All adult patients aged 18 or above admitted to the medical ward of Queen Mary Hospital, the teaching hospital of the University of Hong Kong
- Rectal swabs or stool specimens showing the presence of CRE
- Positive CRE specimen within one week of commencement
Exclusion
- Pregnancy
- Severe immunodeficiency (e.g. advanced human immunodeficiency virus infection (CD4 lymphocyte count ≤200/mm3), myelosuppressive chemotherapy)
- Significant neutropenia (absolute neutrophil count ≤1.0 x 109/L)
- Recent antibiotic use within 30 days prior to consent
- Contraindications for retention enema (intestinal obstruction, ileus and gut perforation).
Key Trial Info
Start Date :
January 1 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
August 19 2025
Estimated Enrollment :
80 Patients enrolled
Trial Details
Trial ID
NCT05981430
Start Date
January 1 2024
End Date
August 19 2025
Last Update
December 7 2023
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