Status:
RECRUITING
The Effectiveness of Vitamin D Supplementation in Patients With End-stage Knee Osteoarthritis
Lead Sponsor:
Chinese University of Hong Kong
Conditions:
Vitamin D Deficiency
Sarcopenia
Eligibility:
All Genders
50+ years
Phase:
NA
Brief Summary
Osteoarthritis (OA) knee is one of the commonest chronic degenerative conditions. It causes disability in elderlies due to pain and stiffness. The prevalence of radiologic knee osteoarthritis increase...
Detailed Description
Osteoarthritis (OA) knee is one of the common chronic degenerative conditions. It causes disability in elders, leading to pain and stiffness. The prevalence of radiologic knee osteoarthritis and sympt...
Eligibility Criteria
Inclusion
- Male and female patients aged over 50 with end-stage knee OA
- Patient are on the waiting list for TKR at Prince of Wales Hospital
- Walk unaided for 6 meters
- Able to comply with the assessments and has given oral and written consent
- Patients with vitamin D insufficiency and deficiency at the baseline measurement (25(OH)D \<30 ng/mL)
Exclusion
- Patients with connective tissue disorders or myositis condition
- History of any Hip \& Knee surgery
- Patients with malnutrition were assessed by Mini-Nutritional assessment.
- Patients with acute immobility (i.e., post-hip fracture or post-acute hospital admission)
- Patient scheduled for TKR within six months
- Patients already taking vitamin D supplements
- Patients with a known contraindication to vitamin D treatment (such as allergy)
- Patients who have renal impairment with glomerular filtration rate (eGFR) \< 30 ml/minute
Key Trial Info
Start Date :
March 17 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
November 30 2025
Estimated Enrollment :
56 Patients enrolled
Trial Details
Trial ID
NCT05981534
Start Date
March 17 2024
End Date
November 30 2025
Last Update
March 27 2024
Active Locations (1)
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1
Prince of Wales Hospital
Hong Kong, Hong Kong