Status:
COMPLETED
Research on Identifying and Treatment Prognosis of Chronic Rhinosinusitis Based on Image and Sequencing Data
Lead Sponsor:
Zheng Liu
Collaborating Sponsors:
Wuhan Central Hospital
First Affiliated Hospital of Zhongshan Medical University
Conditions:
Chronic Sinusitis
Radiology
Eligibility:
All Genders
16-70 years
Brief Summary
This project focuses on researching chronic rhinosinusitis in patients, employing image processing techniques and molecular biology methods to jointly determine the research objectives: 1. Investigat...
Detailed Description
1. Investigating the heterogeneity of chronic rhinosinusitis: the project will utilize high-throughput information from various sources such as radiology, pathology, and proteomics to gain insights in...
Eligibility Criteria
Inclusion
- oral glucocorticoid, and intranasal steroid spray and steroid irrigation treatment were discontinued at least 3 months and 1 month before surgery, respectively;
- without acute asthma episode or acute upper airway infection within 1 month before surgery;
- not under allergen immunotherapy or biologic treatment.
Exclusion
- fungal sinusitis;
- antrochoanal polyps;
- cystic fibrosis, vasculitis, primary ciliary dyskinesia, or immunodeficiency;
- odontogenic maxillary sinusitis;
- patients with history of craniocerebral trauma or sinonasal tumours.
- insufficient CT quality (e.g., metal artifacts, motion artifacts, and lack of intact CT scan of sinuses);
- slice thickness more than 2.5 mm.
- women must not be pregnant, or breast-feeding;
- patients with serious metabolic, cardiovascular, autoimmune, neurology, blood, digestive, cerebrovascular, or respiratory system disease, or any disease interfering with the evaluation of results or affecting subjects safety are excluded, such as glaucoma and tuberculosis;
- patients with emotional or mental problems are excluded;
- patients unsuitable for inclusion based on judgement of researchers are excluded;
Key Trial Info
Start Date :
March 1 2015
Trial Type :
OBSERVATIONAL
Allocation :
ACTUAL
End Date :
April 1 2024
Estimated Enrollment :
3500 Patients enrolled
Trial Details
Trial ID
NCT05983003
Start Date
March 1 2015
End Date
April 1 2024
Last Update
July 24 2025
Active Locations (1)
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1
Department of ENT, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology
Wuhan, Hubei, China, 430030