Status:
COMPLETED
Targeting Default Mode Network Dysfunction in Persons At Risk of Alzheimer's Disease with Non-invasive Techniques
Lead Sponsor:
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Conditions:
Alzheimer Disease
Eligibility:
All Genders
60+ years
Phase:
NA
Brief Summary
Default mode network (DMN) dysfunction is a well-established feature of Alzheimer's Disease (AD) and is already present in preclinical stages and in subjects at risk for AD, thus offering a potential ...
Detailed Description
Sixty-four participants will be enrolled (n=32 APOE e4 carriers, 32 non-carriers as reference group) and will undergo rTMS stimulation, TMS with concurrent electroencephalography (TMS-EEG), multimodal...
Eligibility Criteria
Inclusion
- Age: 60 years and older
- MMSE score \> 24
Exclusion
- Pathological scores in at least two standardized cognitive tests
- Participation in other interventional studies
- Known carriers of an autosomal dominant genetic mutation associated to AD
- Neurological, psychiatric or medical conditions not compatible with the study
- Exclusion Criteria for MRI and rTMS:
- metal implants, pace-makers, prosthetic heart valves
- claustrophobia
- history of epilepsy
- pregnancy
Key Trial Info
Start Date :
December 5 2019
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
December 4 2024
Estimated Enrollment :
86 Patients enrolled
Trial Details
Trial ID
NCT05984446
Start Date
December 5 2019
End Date
December 4 2024
Last Update
January 16 2025
Active Locations (1)
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1
IRCCS Centro San Giovanni di Dio Fatebenefratelli
Brescia, Brescia, Italy, 25125