Status:
COMPLETED
Transcranial Focused Ultrasound (tFUS) Modulation of Reward Network
Lead Sponsor:
Medical University of South Carolina
Conditions:
Healthy
Eligibility:
All Genders
18-65 years
Phase:
NA
Brief Summary
Aim: Evaluate whether sonicating the Nucleus Accumbens (NAc) with transcranial focused ultrasound modifies functional connectivity between the NAc and the prefrontal cortex (PFC). In this single visi...
Eligibility Criteria
Inclusion
- Age 18-65
- Have the capacity and ability to provide one's own consent and sign the informed consent document
Exclusion
- Contraindicated for MRI.
- Any current or recent untreated medical, neurological, or psychiatric conditions
- Metal implant devices in the head, heart, or neck.
- History of brain surgery.
- History of myocardial infarction or arrhythmia, bradycardia.
- Personal or family history of seizure or epilepsy or personal use of medications that substantially reduce seizure threshold (e.g., olanzapine, chlorpromazine, lithium).
- Personal history of head injury, concussion, or self-report of moderate to severe traumatic brain injury.
- Individuals suffering from frequent/severe headaches.
- Individuals with a reported history of psychosis or mania, or individuals who are actively manic or psychotic.
- Regular or recent pain medication use
- Moderate to severe alcohol use (\>3 drinks/day) or illicit substance use (urine confirmed).
- Persons who are pregnant or lactating
Key Trial Info
Start Date :
July 25 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
June 27 2024
Estimated Enrollment :
10 Patients enrolled
Trial Details
Trial ID
NCT05986019
Start Date
July 25 2023
End Date
June 27 2024
Last Update
April 6 2025
Active Locations (1)
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1
Medical University of South Carolina Institute of Psychiatry
Charleston, South Carolina, United States, 29425