Status:
ACTIVE_NOT_RECRUITING
Prevention of Anhedonia in Children
Lead Sponsor:
Vanderbilt University
Collaborating Sponsors:
Nationwide Children's Hospital
Conditions:
Anhedonia
Depression
Eligibility:
All Genders
8-12 years
Phase:
NA
Brief Summary
This trial will test the effects of a positive emotion-focused preventive intervention on reward responsiveness in children of mothers with histories of depression and anhedonia.
Detailed Description
This study will test the effects of a dyadic preventive intervention, Family Promoting Positive Emotion (F-PPE), for 8- to 12-year-old children of mothers with a history of major depressive disorder (...
Eligibility Criteria
Inclusion
- Biological mothers with past or current MDD with anhedonia and their 8- to 12-year-old children
- Child and biological mother can read and speak fluently in English
- Child and mother have access to a computer or tablet and internet for videoconferencing
- For compensation purposes, child and biological mothers must be U.S. citizens
Exclusion
- Children with past or current major depressive disorder (MDD) and/or anhedonia lasting most of the day, nearly every day for at least 2 weeks based on semi-structured interviews will be excluded
- Mothers or children with intellectual or developmental disabilities
- Mothers with past 6 months substance use disorder with moderate or greater severity
- Children or mothers with a lifetime history of a manic or hypomanic episode/bipolar disorder
- Children or mothers with a psychotic disorder (e.g., schizophrenia)
- Children or mothers with visual or hearing impairments that interfere with completing study measures and sessions
- Child offspring of a mother who has previously participated in the study with another biological child
- Children taking medications for emotional or behavioral problems other than SSRIs (stable dose for 6 weeks before time of enrollment) or psychostimulants
Key Trial Info
Start Date :
November 10 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
January 1 2026
Estimated Enrollment :
60 Patients enrolled
Trial Details
Trial ID
NCT05988138
Start Date
November 10 2023
End Date
January 1 2026
Last Update
December 3 2025
Active Locations (1)
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1
Jesup/Hobbs Building
Nashville, Tennessee, United States, 37203