Status:

COMPLETED

Ghrelin and Diastolic Heart Function

Lead Sponsor:

University of Campania Luigi Vanvitelli

Conditions:

Diabetes Mellitus, Type 2

Obesity, Abdominal

Eligibility:

All Genders

18-75 years

Brief Summary

In type 2 diabetes mellitus (T2DM) and obese patients the adipose tissue could over-express cytokines, sirtuin-1 (SIRT1), and microRNAs (miRs) implied in the regulation of left ventricle (LV) diastoli...

Eligibility Criteria

Inclusion

  • Clinical diagnosis of T2DM obese patients;
  • T2DM obese patients under anti-diabetic full medical therapy and glycemic control.

Exclusion

  • clinical diagnosis of type 1 diabetes;
  • T2DM patients in poor glycemic control (HbA1c values of \>7%);
  • chronic neurological disorders;
  • heart failure and coronary heart disease or depression of left ventricular ejection fraction (LVEF \<55%);
  • severe anemia;
  • thyroid dysfunction;
  • kidney failure;
  • uncontrolled blood pressure (blood pressure \> 140/90 mmHg on two occasions 2 weeks apart);
  • inflammatory chronic disease;
  • neoplastic disease.

Key Trial Info

Start Date :

January 1 2016

Trial Type :

OBSERVATIONAL

Allocation :

ACTUAL

End Date :

March 1 2022

Estimated Enrollment :

60 Patients enrolled

Trial Details

Trial ID

NCT05988346

Start Date

January 1 2016

End Date

March 1 2022

Last Update

August 24 2023

Active Locations (1)

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Celestino Sardu

Naples, Italy, 80138