Status:
COMPLETED
Diagnostic Stewardship for Ventilator Associated Pneumonia
Lead Sponsor:
University of Maryland, Baltimore
Collaborating Sponsors:
Centers for Disease Control and Prevention
George Washington University
Conditions:
Ventilator Associated Pneumonia
Eligibility:
All Genders
18+ years
Phase:
NA
Brief Summary
The goal of this pragmatic cluster-randomized crossover trial is to test if less unnecessary antibiotics are prescribed when the lab reports respiratory culture test results in a specific way for pati...
Detailed Description
The specific aims of this project are: Specific Aim 1: In a cluster-randomized crossover trial among 6 ICUs across 3 medical centers, evaluate the impact of a VAP diagnostic stewardship intervention ...
Eligibility Criteria
Inclusion
- Patient located on ICU unit included in the study
- Patient is mechanically ventilated
- Patient had respiratory culture sent \>48 hours after admission
- Patient age ≥ 18 years
Exclusion
- Extra corporeal membrane oxygenation (ECMO) at time of respiratory culture
- Heart or lung transplant
- Culture rejected by lab per standard lab protocol
- Prisoners
- Severe immunosuppression as defined by:
- \<6 months from solid organ transplant (SOT) OR \<6 months from treatment for acute rejection following SOT
- Active treatment for lymphoreticular malignancies
- Neutropenic \< 1000
- Receiving lymphodepleting chemotherapy
- Allogeneic stem cell transplants \<6 months
- Autologous stem cell transplants or chimeric antigen receptor T-cell (CAR-T) therapy \<6 months out
- Allogeneic stem cell transplant with graft vs host disease (GVHD) or receiving 2 or more immunosuppressants
- Advanced or untreated human immunodeficiency virus (HIV) infection with CD4 \< 200
- Receiving biologics within 6 months
Key Trial Info
Start Date :
August 21 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
March 30 2025
Estimated Enrollment :
161 Patients enrolled
Trial Details
Trial ID
NCT05989269
Start Date
August 21 2023
End Date
March 30 2025
Last Update
November 24 2025
Active Locations (3)
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1
University of Maryland
Baltimore, Maryland, United States, 21201
2
Baylor College of Medicine
Houston, Texas, United States, 77030
3
Virginia Commonwealth University
Richmond, Virginia, United States, 23284