Status:
RECRUITING
Chronic Hypertension and Pregnancy 2 (CHAP2) Pilot Project
Lead Sponsor:
University of Alabama at Birmingham
Conditions:
Hypertension in Pregnancy
Eligibility:
FEMALE
14-89 years
Phase:
PHASE1
Brief Summary
The CHAP2 study is designed to provide preliminary data for a larger multicenter study to assess whether treatment of stage 1 hypertension (HTN) in pregnancy improves maternal and or neonatal outcomes...
Eligibility Criteria
Inclusion
- Viable singleton gestation
- No fetal anomalies
- Blood pressures 130-139/80-89mmHg on two occasions at least 4 hours apart prior to 20 weeks gestation
- Planning to deliver at UAB Hospital
- No indication for pregnancy termination
- Receiving care at the UAB prenatal clinics
Exclusion
- Declines Randomization
- Known diagnosis of chronic hypertension ( BP ≥ 140/90mmHg) or current antihypertensive medication use
- Fetal demise diagnosed prior to enrollment
- Known major structural of chromosomal abnormalities prior to enrollment
- Contraindication to first line antihypertensive (Nifedipine/ Labetalol)
- Comorbidities requiring BP goals \< 130/80mmHg
Key Trial Info
Start Date :
April 24 2024
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
June 30 2026
Estimated Enrollment :
74 Patients enrolled
Trial Details
Trial ID
NCT05989581
Start Date
April 24 2024
End Date
June 30 2026
Last Update
May 31 2025
Active Locations (1)
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1
UAB
Birmingham, Alabama, United States, 35294