Status:
UNKNOWN
Brain Activity Among Children With Overactive Bladder and Daytime Urinary Incontinence and Healthy Children
Lead Sponsor:
Aalborg University Hospital
Collaborating Sponsors:
Aarhus University Hospital
Regional Hospital West Jutland
Conditions:
Urinary Incontinence
Daytime Wetting
Eligibility:
All Genders
6-14 years
Phase:
NA
Brief Summary
The aim of this study is to investigate whether the activity in brain areas controlling the bladder is different among children suffering from Overactive Bladder (OAB) and Daytime Urinary Incontinence...
Detailed Description
Daytime Urinary Incontinence (DUI) is a common condition among children affecting 2.1-21.8 % of children aged 4.5-17 years. DUI is most often caused by a functional overactive bladder (OAB) leading to...
Eligibility Criteria
Inclusion
- Overactive Bladder as per International Children's Continence Society criteria (cases only).
- At least 2 incontinence episodes per week (cases only).
- No urinary tract symptoms (healthy participants only).
- More than 3 daily urinations.
- Normal clinical examination.
Exclusion
- Known urogenital abnormality affecting the lower urinary tract function.
- Prior surgery in the urinary tract (except circumcision).
- Known neurological diseases or prior cerebral surgery.
- Known neuropsychiatric disorders or suspicion of those by screening.
- Treatment with pharmacological agents affecting the brain function.
- Prior treatment with Enuresis Alarm or Transcutaneous Electrical Nerve Stimulation.
- Prior or current treatment with mirabegron or oxybutynin.
- Current urinary tract infection.
- Current constipation according to Rome IV-criteria or faecal incontinence.
- Claustrophobia.
- Metallic items in the body contraindicating MRI-scans.
- Abnormal uroflowmetry (healthy participants only).
Key Trial Info
Start Date :
May 5 2021
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
April 1 2024
Estimated Enrollment :
65 Patients enrolled
Trial Details
Trial ID
NCT05989646
Start Date
May 5 2021
End Date
April 1 2024
Last Update
August 14 2023
Active Locations (4)
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1
Department of Pediatrics, Aalborg University Hospital
Aalborg, Denmark, 9000
2
Department of Pediatrics, Aarhus University Hospital
Aarhus, Denmark, 8200
3
Department of Pediatrics, Regional Hospital West Jutland
Herning, Denmark, 7400
4
Department of Pediatrics, North Denmark Regional Hospital
Hjørring, Denmark, 9800