Status:
RECRUITING
Pituitary Function After Recovery From Septic Shock Among ICU Survivors
Lead Sponsor:
Sanjay Gandhi Postgraduate Institute of Medical Sciences
Conditions:
Shock, Septic
Pituitary Dysfunction
Eligibility:
All Genders
18-80 years
Brief Summary
Prolonged circulatory shock is associated with marked disturbances in vascular supply to the brain, and endothelial dysfunction which can lead to disseminated intravascular coagulation and microvascul...
Detailed Description
The pituitary gland receives its arterial blood supply from the superior and inferior hypophyseal arteries, which arise from the internal carotid artery. The infundibulum, the median eminence and the ...
Eligibility Criteria
Inclusion
- Septic shock group:
- Patients 18-80 years of age who meet the definition of septic shock.
- Vasopressor requirement should be maintained for a period \> 24 hours and should require ICU stay for a duration of \> 7 days.
- Patient should recover from shock and be planned for discharge from the ICU
- Non-septic shock group
- Patients 18-80 years of age who planned for discharge from the ICU.with stay for a duration of \>7 days.
- Also, they should not have received vasopressor for.a period of \>24 hours
Exclusion
- Patients who refuse to provide consent.
- Age \<18 years or \> 80 years of age.
- Pregnancy or immediate post-partum (\< 6 months post-delivery).
- Chronic kidney disease (Stage 5), chronic liver disease (CHILD B or C), severe Chronic obstructive pulmonary disease, Chronic heart failure.
- Patients with pre-existing hypopituitarism on replacement.
- Past history of severe post-partum hemorrhage requiring blood transfusion, traumatic brain injury, subarachnoid hemorrhage, pituitary tumor/surgery, snake bite envenomation and meningo-encephalitis.
- Patients who have been on \> 5 mg prednisolone equivalent for a period of more than 2 weeks at any time in the previous 6 months before admission.
Key Trial Info
Start Date :
August 28 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
August 1 2025
Estimated Enrollment :
90 Patients enrolled
Trial Details
Trial ID
NCT05990491
Start Date
August 28 2023
End Date
August 1 2025
Last Update
October 15 2024
Active Locations (2)
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1
Department of Critical Care Medicine, SGPGIMS
Lucknow, Uttar Pradesh, India, 226014
2
Department of Endocrinology, SGPGIMS
Lucknow, Uttar Pradesh, India, 226014