Status:
RECRUITING
The Effect of Desflurane Versus Sevoflurane Versus Propofol on Postoperative Delirium
Lead Sponsor:
Medical University of Vienna
Collaborating Sponsors:
Medical University Innsbruck
Conditions:
Postoperative Delirium
Major Noncardiac Surgery
Eligibility:
All Genders
65+ years
Phase:
PHASE4
Brief Summary
Patients over the age of 65 years are at increased risk for developing delirium after noncardiac surgeries, resulting in increased morbidity and mortality. The prevention of postoperative delirium has...
Detailed Description
Background: Postoperative delirium occurs in approximately 25% of patients over the age of 60 years undergoing major noncardiac surgery and is significantly associated with an increase in postoperativ...
Eligibility Criteria
Inclusion
- Provide written informed consent
- ≥65 years of age
- Scheduled for elective major noncardiac surgery with estimated time of surgery ≥ 2 hours
Exclusion
- Patients undergoing emergency surgery
- BMI \> 45 kg/m\^2
- History of diagnosed dementia
- Language, vision, or hearing impairments that may compromise cognitive assessments
- History of malignant hyperthermia
- History of structural muscle disease
- History of organ transplantation (kidney, liver, lung, heart)
- Patients undergoing hyperthermic intraperitoneal chemotherapy
- ICU patients undergoing surgery
Key Trial Info
Start Date :
September 3 2023
Trial Type :
INTERVENTIONAL
Allocation :
ESTIMATED
End Date :
December 31 2028
Estimated Enrollment :
1332 Patients enrolled
Trial Details
Trial ID
NCT05990790
Start Date
September 3 2023
End Date
December 31 2028
Last Update
April 30 2025
Active Locations (2)
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1
Medical University of Innsbruck
Innsbruck, Austria, 6020
2
Medical University of Vienna
Vienna, Austria, 1090