Status:
COMPLETED
Evaluate the Effect of Clarithromycin/Rifampicin on the Pharmacokinetics of DA-8010 in Healthy Adults
Lead Sponsor:
Dong-A ST Co., Ltd.
Conditions:
Healthy
Eligibility:
All Genders
19-50 years
Phase:
PHASE1
Brief Summary
This is an open-label, fixed-sequence, phase 1 study to evaluate the effect of clarithromycin/rifampicin on the pharmacokinetics of DA-8010 in healthy adults.
Eligibility Criteria
Inclusion
- Healthy adult volunteer 19 years to 50 years
- Body weight in the range of 40.0 to 90.0 kg and body mass index in the range of 18 to 28kg/m2
- In the case of female volunteers, those who are not necessarily pregnant or lactating or who are in a surgical infertility condition (both tubular obstruction, hysterectomy, bilateral tubular resection, etc.)
- The subjects personally signed and dated informed consent document after informed of all patient aspects of the study, fully understanding and determined spontaneously to participate
- The subjects who are judged appropriate to participate this clinical trial according to the physical examination, routine laboratory examination and questionnaire
Exclusion
- Subject with serious active hepatobiliary (severe hepatic failure, etc.), renal(severe renal impairment, etc.), neurologic, immunologic, respiratory, digestive, endocrine, hematologic, cardiovascular(heart failure, Torsades de pointes, etc), urologic, psychological disease, sexual disorder, ophthalmologic or history of such disease
- Subject with gastrointestinal disease (peptic ulcer, gastritis, gastrospasm, gastroesophageal reflux disease, Crohn's disease, etc.) or history of such disease/surgery (excluding simple appendix surgery, hernia surgery, hemorrhoid surgery)
- Subject Hypersensitive to any of the IP components or other drug components(Aspirin, Antibiotics, etc.)
- Subject who is positive for serum test results (hepatitis B test, hepatitis C test, HIV test, syphilis test)
- Subject who have history of drug/alcohol abuse or Positive in Urine drug screen test
- Subject who determined that Investigator is unfit to participate in a clinical trial due to other reasons other than the above items
Key Trial Info
Start Date :
August 18 2023
Trial Type :
INTERVENTIONAL
Allocation :
ACTUAL
End Date :
November 17 2023
Estimated Enrollment :
18 Patients enrolled
Trial Details
Trial ID
NCT05991401
Start Date
August 18 2023
End Date
November 17 2023
Last Update
January 25 2024
Active Locations (1)
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1
Seoul National University Hospital
Seoul, South Korea