Status:
ACTIVE_NOT_RECRUITING
Extreme Morphology and Metabolic Health
Lead Sponsor:
University of Bath
Collaborating Sponsors:
University of Bristol
Conditions:
Skeletal Dysplasia
Eligibility:
All Genders
16+ years
Brief Summary
Researchers at the University of Bath are investigating the metabolism of individuals with extreme body size, including those with skeletal dysplasia (commonly known as dwarfism), to manage health ris...
Detailed Description
After signing informed consent to take part in the study, participants will be asked to complete a health entry criteria questionnaire, including a physical activity readiness questionnaire and Eating...
Eligibility Criteria
Inclusion
- Aged 16 years or over
- Any diagnosed form of skeletal dysplasia (i.e., extreme proportionate or disproportionate short stature)
- Individuals without skeletal dysplasia but presenting with extreme body morphology, defined as: individuals with extreme large body morphology (males \>75 kg fat-free mass and females \>57.25 kg fat-free mass), or males and females with extreme small body morphology (\<47.4 kg fat-free mass).
Exclusion
- Any reported condition, behaviour or reported use of substances which may pose undue personal risk to the participant or introduce bias into the study, except for any which are ubiquitous in society and so would be equally distributed between groups and/or therefore relevant to generalisation (e.g., statins, caffeine, GLP-1 agonists).
- Females who are pregnant or lactating
- Individuals with a diagnosed history of eating disorders (e.g., anorexia)
- Individuals with known bleeding disorders (exclusion for biopsies only)
- Individuals with known allergy or intolerance to lidocaine
- Inability to read or speak English, or otherwise to consent to procedures
- Individuals who are not weight stable (i.e., \>3 kg change in body mass in past 3 months)
Key Trial Info
Start Date :
June 17 2023
Trial Type :
OBSERVATIONAL
Allocation :
ESTIMATED
End Date :
September 28 2035
Estimated Enrollment :
102 Patients enrolled
Trial Details
Trial ID
NCT05991609
Start Date
June 17 2023
End Date
September 28 2035
Last Update
February 10 2025
Active Locations (1)
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1
University of Bath
Bath, United Kingdom, BA27AY